A reader asks:

 Is there any report of hypomanic episodes with negative air ion therapy?

Answer:

In formal clinical trials, when side effects were measured, there were no indication of hypomanic episodes. However, clinical cases include a small number of users who have become “wired” (or hypomanic) with negative air ion overdose — when, for example, they leave the ionizer on all night. It is safest to use the method as has been investigated: for 30 minutes after waking or 90 minutes before waking (automatically switched on and off by an electronic timer).