CET’S Survey of Basic Research and Clinical Landmarks in Chronobiology and Chronotherapy:

A Literature Resource and Introduction

This overview covers the influence of the circadian timing system on behavior, sleep, psychological states, and medical illness.

Sixteen key topics within the discipline are packed within two broad categories—Circadian Science and Clinical Applications—like two layers of chocolates in a gift box. And within each chocolate, a filling of books, reviews, and studies, culled from thousands of scientific publications, is designed to please every scholarly taste.

The public may be sated with just the introductions to these confections: the ganache, and not the filling.  The introductions explain milestones in the discipline that are impressive even today, and may surprise the reader. For example, who would have guessed that the light that strikes the eye activates two different systems: one for vision, and one for the inner clock which regulates our circadian rhythms?

But let us not steal our own thunder. Instead, let us invite you to enjoy the resources Jiuan and Michael Terman have chosen for their historic and future value, rather than their rank on a search engine. Whether you are browsing out of curiosity, or looking for a reference for a grant proposal, we hope this Treasury, updated as new discoveries are made, will tease, tempt, and satisfy your palate!

Circadian Science

I.  Origins of Understanding of the Circadian Timing System and Its Free-Running Clock
II. Locating the Circadian Clock in the Brain
III. The Effect of Timing of Light Exposure on Circadian Rhythms (Entrainment and Phase-Shifting)
IV. The Eye as Light Transducer to the Circadian Clock: Melanopsin as a Circadian Phototransducer
V. The Spectrum of Light for Activating the Circadian Clock Response
VI. Non-Photic Influences on the Circadian Timing System

Clinical Applications

VII. Seasonal Affective Disorder and Light Therapy
VIII. Later Demonstrations of Light Therapy for Psychiatric Disorders
IX. Circadian Rhythm Sleep Disorders and Their Treatment
X. Circadian Properties of Melatonin and Its Relationship to Sleep
XI. Circadian Analysis of Jet Lag, and Treatment Approaches
XII. Circadian Analysis of Shift Work Disorder, and Treatment Approaches
XIII. Prospects for New Applications of Light Therapy
XIV. Chronotherapeutics: Light and Wake Therapy
XV. Chronotype, Circadian Clock Phase, and Period
XVI. Circadian Rhythm Influences on Medical Conditions, and Risk Factors